Knockout Validated Antibodies

A high-quality antibody demonstrates target specificity, selectivity, and sensitivity, enabling it to accurately detect the protein of interest even at low expression levels. Nevertheless, cross-reactivity with off-target proteins is still a concern with some antibodies. This challenge may present issues with experimental reproducibility, as non-specific antibodies can impede scientific progress.

MBLI introduces Knockout [KO] validation as the standard of antibody confirmation.  The gene knockout validation is used to determine the function of a known sequence. By inactivating the gene that encodes the target protein, we can produce samples with a depletion of the target protein. KO validation is a highly effective technique that confirms the specificity of the antibody as depicted.

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Production and Quality Control

A high-quality antibody demonstrates: 

• Target specificity
• Target selectivity
• Target sensitivity
• Accurately detect the protein of interest even at low expression levels
  

Representative data demonstrating that the molecular weights measured with KO knockout validated Antibodies and wild type antibodies:

Product Offerings

MBLI offers over 300 Knockout [KO] validated antibodies! Please reach out to us for more product information.

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