Please Note: MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: https://www.cosmobiousa.com/. For Non-US inquiries reach out to MBL in Japan: https://www.mblbio.com/.

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Reagents for SARS-CoV-2

SARS-CoV-2 is the virus that causes the COVID-19 disease (Coronovirus Disease 2019). MBLI understands the urgent need to have better understanding and characterization of this disease in order to find treatments and vaccines. We are continuing to develop and launch new products for the research community as fast as we can.

T-cells are activated only by interacting with processed peptides (e.g. of SARS-CoV-2) that sit in the groove of MHC Class I and II molecules. Identifying these peptides can be used (in forms of peptide-MHC tetramers) to asses vaccine induced immunity and to assist in designing potent vaccines with durable responses. COVID-19 infected cells can be recognized by T-cells only after SARS-CoV-2 peptides are processed and presented in the context of self MHCs. Identifying these peptides has essential utilities:

  • Immune monitoring: Using peptide-MHC tetramers to assess vaccine-induced immunity
  • Designing potent vaccines that elicit durable responses

MBL International can assist companies and academic investigators who are actively developing coronavirus vaccines with our unique QuickSwitch™ custom tetramer platform. QuickSwitch™ is a peptide screening plug and play platform that identifies peptides that are more likely to be immunogenic and yet generates corresponding Class I and Class II MHC tetramers. This platform can identify and validate multi-epitope candidates of SARS-CoV-2 proteins that can potentially elicit for both CD4+ and CD8+ T-cell immune responses. By using MBLI’s MHC tetramer exchange QuickSwitch™ platform for peptide screening, you can identify/validate the binding of predicted peptide sequences of the COVID-19 viral proteins in most common alleles: HLA-A2, A11, A24, A3 and HLA-DR1, DR4, DR15.

We are excited to offer QuickSwitch kit and peptide bundles specifically for SARS-CoV-2 research. Discover more about the kits and peptide sequences in each bundle by clicking the button below:

QuickSwitch™ kit & peptides bundle

Product Highlights

MHC Tetramers for COVID-19 Cell Detection
Product Code Class Sequence Target
TB-0174-1 Class I RLNEVAKNL HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0174-2 Class I RLNEVAKNL HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0174-4 Class I RLNEVAKNL HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0174-M Class I RLNEVAKNL Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0174-M2 Class I RLNEVAKNL Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0175-1 Class I KLPDDFTGCV HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0175-2 Class I KLPDDFTGCV HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0175-4 Class I KLPDDFTGCV HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0175-M Class I KLPDDFTGCV Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0175-M2 Class I KLPDDFTGCV Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0176-1 Class I YLQPRTFLL HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0176-2 Class I YLQPRTFLL HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0176-4 Class I YLQPRTFLL HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer
TB-0176-M Class I YLQPRTFLL Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0176-M2 Class I YLQPRTFLL Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0177-1 Class I RLQSLQTYV HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer-
TB-0177-2 Class I RLQSLQTYV HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer-
TB-0177-4 Class I RLQSLQTYV HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Tetramer-
TB-0177-M Class I RLQSLQTYV Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer
TB-0177-M2 Class I RLQSLQTYV Biotinylated HLA-A*02:01 SARS-CoV-2 Spike Glycoprotein Monomer


Peptides for COVID-19 Cell Detection

SPC001 SARS-CoV-2 ORF1ab polyprotein (3906-3920) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 EAFEKMVSLLSVLLS
SPC002 SARS-CoV-2 ORF1ab polyprotein (471-485) Peptide HLA-DRB1*01:01, HLA-DRB1*15:01 EEIAIILASFSASTS
SPC003 SARS-CoV-2 ORF1ab polyprotein (1801-1815) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 ESPFVMMSAPPAQYE
SPC004 SARS-CoV-2 envelope protein (56-70) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 FYVYSRVKNLNSSRV
SPC005 SARS-CoV-2 ORF1ab polyprotein (2211-2225) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 LEASFNYLKSPNFSK
SPC006 SARS-CoV-2  nucleocapsid phosphoprotein (221-235)  Peptide HLA-DRB1*01:01 LLLLDRLNQLESKMS
SPC007 SARS-CoV-2 membrane glycoprotein (176-190) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 LSYYKLGASQRVAGD
SPC008 SARS-CoV-2 ORF3a protein (1-15) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 MDLFMRIFTIGTVTL
SPC009 SARS-CoV-2 membrane glycoprotein (91-105) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 MWLSYFIASFRLFAR
SPC010 SARS-CoV-2 ORF1ab polyprotein (5016-5030) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 RAMPNMLRIMASLVL
SPC011 SARS-CoV-2 ORF1ab polyprotein (3946-3960) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 SEFSSLPSYAAFATA
SPC012 SARS-CoV-2 chain A spike glycoprotein (236-250)  Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 TRFQTLLALHRSYLT
SPC013 SARS-CoV-2  nucleocapsid phosphoprotein (301-315)  Peptide HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 WPQIAQFAPSASAFF
SPC014 SARS-CoV-2 ORF3a protein (206-220) Peptide HLA-DRB1*01:01, HLA-DRB1*04:01 YFTSDYYQLYSTQLS
SPC015 SARS-CoV-2  ORF1ab (3122-3130)  Peptide HLA-A*02:01 FLAHIQWMV
SPC016 SARS-CoV-2  ORF1ab (3183-3191)  Peptide HLA-A*02:01 FLLNKEMYL
SPC017 SARS-CoV-2  ORF1ab (6749-6758)  Peptide HLA-A*02:01 LLLDDFVEII
SPC018 SARS-CoV-2  ORF3a protein (139-147)  Peptide HLA-A*02:01 LLYDANYFL
SPC019 SARS-CoV-2  ORF1ab (3732-3740)  Peptide HLA-A*02:01 SMWALIISV
SPC020 SARS-CoV-2  ORF1ab (3710-3718)  Peptide HLA-A*02:01 TLMNVLTLV
SPC021 SARS-CoV-2  ORF1ab (6419-6427)  Peptide HLA-A*02:01 YLDAYNMMI
SPC022 SARS-CoV-2  ORF1ab (6851-6859)  Peptide HLA-A*02:01 YLNTLTLAV
SPC023 SARS-CoV-2  ORF3a protein (107-115)  Peptide HLA-A*02:01 YLYALVYFL
SPC024 SARS-CoV-2  ORF1ab (2192-2200)  Peptide HLA-A*03:01, HLA-A*11:01 ASMPTTIAK
SPC025 SARS-CoV-2  ORF1ab (4892-4900)  Peptide HLA-A*03:01, HLA-A*11:01 KSAGFPFNK
SPC026 SARS-CoV-2  nucleocapsid phosphoprotein (362-370)  Peptide HLA-A*03:01, HLA-A*11:01 KTFPPTEPK
SPC027 SARS-CoV-2  ORF1ab (2600-2608)  Peptide HLA-A*03:01, HLA-A*11:01 STFNVPMEK
SPC028 SARS-CoV-2  ORF1ab (1875-1883)  Peptide HLA-A*03:01, HLA-A*11:01 TTIKPVTYK
SPC029 SARS-CoV-2  ORF1ab (6159-6167)  Peptide HLA-A*24:02 DYVYNPFMI
SPC030 SARS-CoV-2  ORF1ab (4986-4994)  Peptide HLA-A*24:02 FYGGWHNML
SPC031 SARS-CoV-2  ORF1ab (3159-3167)  Peptide HLA-A*24:02 NYLKRRVVF
SPC032 Chain A, SARS-CoV-2 spike glycoprotein (539-546) Peptide H-2 Kb VNFNFNGL
SPC033 Chain A, SARS-CoV-2 spike glycoprotein (902-909) Peptide H-2 Kb MAYRFNGI
SPC034 Chain A, SARS-CoV-2 spike glycoprotein (233-241) Peptide H-2 Kb INITRFQTL
SPC035 Chain A, SARS-CoV-2 spike glycoprotein (511-518) Peptide H-2 Kb VVLSFELL
SPC036 Chain A, SARS-CoV-2 spike glycoprotein (325-332) Peptide H-2 Kb SIVRFPNI
SPC037 Chain A, SARS-CoV-2 spike glycoprotein (447-455) Peptide H-2 Kb GNYNYLYRL
SPC038 Chain A, SARS-CoV-2 spike glycoprotein (1060-1068) Peptide HLA-A*02:01, H-2 Kb VVFLHVTYV
SPC039 Chain A, SARS-CoV-2 spike glycoprotein (691-699) Peptide HLA-A*02:01, H-2 Kb SIIAYTMSL
SPC040 Chain A, SARS-CoV-2 spike glycoprotein (424-433) Peptide HLA-A*02:01 KLPDDFTGCV
SPC041 ORF1ab polyprotein SARS-CoV-2 (5385-5393) Peptide H-2 Kb VTQLYLGGM
SPC042 ORF1ab polyprotein SARS-CoV-2 (5583-5591) Peptide HLA-A*02:01 ISDEFSSNV
SPC043 ORF1ab polyprotein SARS-CoV-2 (5573-5580) H-2 Kb ITGLYPTL
SPC044 Chain A, SARS-CoV-2 spike glycoprotein (263-270) H-2 Kb AAYYVGYL
SPC045 Chain A, SARS-CoV-2 spike glycoprotein (449-456) H-2 Kb YNYLYRLF
SPC046 SARS-CoV-2 chain A spike glycoprotein (363-377)  HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 ADYSVLYNSASFSTF
SPC047 SARS-CoV-2 surface glycoprotein (1216-1230) HLA-DRB1*01:01, HLA-DRB1*04:01 IWLGFIAGLIAIVMV
SPC048 SARS-CoV-2 envelope protein (21-35) HLA-DRB1*01:01 LAFVVFLLVTLAILT
SPC049 SARS-CoV-2 ORF7a protein (1-15) HLA-DRB1*01:01, HLA-DRB1*04:01 MKIILFLALITLATC
SPC050 SARS-CoV-2 membrane glycoprotein (41-55) HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 NRNRFLYIIKLIFLW
SPC051 SARS-CoV-2 chain A spike glycoprotein (509-523)  HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*15:01 RVVVLSFELLHAPAT
SPC052 SARS-CoV-2 chain A spike glycoprotein (51-65)  HLA-DRB1*04:01, HLA-DRB1*15:21 TQDLFLPFFSNVTWF
SPC053 SARS-CoV-2 Spike Glycoprotein Peptide-RLNEVAKNL    HLA-A*02:01   RLNEVAKNL 
SPC054 SARS-CoV-2 Spike Glycoprotein Peptide-YLQPRTFLL    HLA-A*02:01   YLQPRTFLL  
SPC055 SARS-CoV-2 Spike Glycoprotein Peptide-RLQSLQTYV    HLA-A*02:01   RLQSLQTYV  
SPC056 Chain A, SARS-CoV-2 spike glycoprotein (495-503) wild type  HLA-A*02:01   YGFQPTNGV
SPC057 Chain A, SARS-CoV-2 spike glycoprotein (495-503) N501Y mutant  HLA-A*02:01   YGFQPTYGV
SPC058 Chain A, SARS-CoV-2 spike glycoprotein (484-492) wild type  HLA-A*02:01   EGFNCYFPL
SPC059 Chain A, SARS-CoV-2 spike glycoprotein (484-492) E484K mutant  HLA-A*02:01   KGFNCYFPL
SPC060 Chain A, SARS-CoV-2 spike glycoprotein (493-501) N501Y mutant  HLA-A*03:01   QSYGFQPTY
SPC062 SARS-CoV-2  ORF1ab polyprotein (1326-1334)  HLA-A*01:01 PTDNYITTY
SPC063 SARS-CoV-2  ORF1ab polyprotein (1642-1650)  HLA-A*01:01 TTDPSFLGR
SPC064 SARS-CoV-2 chain A spike glycoprotein (255-263)  HLA-A*01:01 WTAGAAAYY
SPC065 SARS-CoV-2 chain A spike glycoprotein (958-966)  HLA-A*02:01 ALNTLVKQL
SPC066 SARS-CoV-2 ORF3a protein (75-83) HLA-A*02:01 ALSKGVHFV
SPC067 SARS-CoV-2  ORF1ab polyprotein (4099-4107)  HLA-A*02:01 ALWEIQQVV
SPC068 SARS-CoV-2 chain A spike glycoprotein (1220-1228)  HLA-A*02:01 FIAGLIAIV
SPC069 SARS-CoV-2  nucleocapsid phosphoprotein (316-324)  HLA-A*02:01 GMSRIGMEV
SPC070 SARS-CoV-2  nucleocapsid phosphoprotein (351-359)  HLA-A*02:01 ILLNKHIDA
SPC071 SARS-CoV-2  ORF1ab polyprotein (3891-3899)  HLA-A*02:01 KLWAQCVQL
SPC072 SARS-CoV-2  nucleocapsid phosphoprotein (222-230)  HLA-A*02:01 LLLDRLNQL
SPC073 SARS-CoV-2 chain A spike glycoprotein (1192-1200)  HLA-A*02:01 NLNESLIDL
SPC074 SARS-CoV-2 membrane glycoprotein (61-70) HLA-A*02:01 TLACFVLAAV
SPC075 SARS-CoV-2 chain A spike glycoprotein (958-966)  HLA-A*02:01 VLNDILSRL
SPC076 SARS-CoV-2 membrane glycoprotein (171-180) HLA-A*03:01, HLA-A*11:01 ATSRTLSYYK 
SPC077 SARS-CoV-2 chain A spike glycoprotein (378-386)  HLA-A*03:01, HLA-A*11:01 KCYGVSPTK 
SPC078 SARS-CoV-2  ORF1ab polyprotein (4678-4686)  HLA-A*03:01, HLA-A*11:01 KLFDRYFKY
SPC079 SARS-CoV-2  ORF1ab polyprotein (282-290)  HLA-A*03:01, HLA-A*11:01 KTIQPRVEK
SPC081 SARS-CoV-2 chain A spike glycoprotein (454-462)  HLA-A*03:01, HLA-A*11:01 RLFRKSNLK
SPC082 SARS-CoV-2  ORF1ab polyprotein (4221-4229)  HLA-A*03:01, HLA-A*11:01 VTDTPKGPK 
SPC083 SARS-CoV-2  ORF1ab polyprotein (5538-5547)  HLA-A*03:01, HLA-A*11:01 VVYRGTTTYK
SPC084 SARS-CoV-2  nucleocapsid phosphoprotein (134-143)  HLA-A*11:01 ATEGALNTPK
SPC085 SARS-CoV-2  ORF1ab polyprotein (282-290)  HLA-A*24:02 FYAYLRKHF
SPC086 SARS-CoV-2 chain A spike glycoprotein (454-462)  HLA-A*24:02 QYIKWPWYI
SPC087 SARS-CoV-2 chain A spike glycoprotein (78-86)  HLA-A*24:02 RFDNPVLPF
SPC088 SARS-CoV-2 ORF3a protein (114-122) HLA-A*24:02 VYFLQSINF
SPC089 SARS-CoV-2  ORF1ab polyprotein (5726-5734)  HLA-A*24:02 VYIGDPAQL
SPC090 SARS-CoV-2  ORF1ab polyprotein (1541-1549)  HLA-A*24:02 YYTSNPTTF
SPC091 SARS-CoV-2  ORF1ab polyprotein (2954-2962)  HLA-B*07:02 RPDTRYVLM
SPC092 SARS-CoV-2  ORF1ab polyprotein (5921-5929)  HLA-B*07:02 IPRRNVATL
SPC093 SARS-CoV-2  ORF1ab polyprotein (2954-2961)  HLA-B*07:02 RPDTRYVL
SPC094 SARS-CoV-2 chain A spike glycoprotein (1056-1063)  HLA-B*07:02 APHGVVFL
SPC095 SARS-CoV-2  ORF1ab polyprotein (4168-4176)  HLA-A*01:01 CTDDNALAY
SPC096 SARS-CoV-2 Spike Glycoprotein Peptide Omicron variant (367-376) (S371D, S373P, S375F) HLA-A*02:01 VLYNLAPFFT 
SPC097 SARS-CoV-2 Spike Glycoprotein Peptide WT (367-376) HLA-A*02:01 VLYNSASFST 
SPC098 SARS-CoV-2 Spike Glycoprotein Peptide Omicron variant (367-378) (S371D, S373P, S375F) HLA-A*03:01 VLYNLAPFFTFK 
SPC099 SARS-CoV-2 Spike Glycoprotein Peptide WT (367-378) HLA-A*03:01 VLYNSASFSTFK 
SPC100 SARS-CoV-2 Spike Glycoprotein Peptide Omicron variant (366-378) (S371D, S373P, S375F) HLA-A*11:01 SVLYNLAPFFTFK 
SPC101 SARS-CoV-2 Spike Glycoprotein Peptide WT (366-378) HLA-A*11:01 SVLYNSASFSTFK 
SPC102 SARS-CoV-2 Spike Glycoprotein Peptide Omicron variant (368-377) (S371D, S373P, S375F) HLA-A*24:02 LYNLAPFFTF 
SPC103 SARS-CoV-2 Spike Glycoprotein Peptide WT (368-377) HLA-A*24:02 LYNSASFSTF 

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Contact us today if you have specific needs that you do not see listed here. We’re here to help advance your COVID-19 research.

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